I've run ESI's for years. I tried to go back to the Specialized lock-ons that came on my bike, but that only lasted one ride. ESI's last for a really long time if you don't care that the ends look like they were chewed up by a beaver. That's not the part that contacts your hands anyway. That and those plastic plugs only last one ride. I use wine corks instead. Ghetto, yes, but I don't really care. If that stuff does bother you, Red Monkey Klampz may work better (never tried them personally). https://www.jensonusa.com/Red-Monkey-Klampz-Lock-on-Grips-Orange-W-Black-Clamps?pt_source=googleads&pt_medium=cpc&pt_campaign=shopping_us&pt_keyword=&gclid=Cj0KCQjw_5rtBRDxARIsAJfxvYCmeQSkRygaP--ad5oGVK7thG_BIrT2tqXAS8wXKgsqCzMBtcxod6YaArw5EALw_wcB
I've dealt with a lot of hand/wrist pain and numbness. Having a job where I'm on a computer all day sure doesn't help. A grip can only go so far. I've tried all kinds of things like crazy sweepy bars and Ergon grips. The two things that have really help me are brake lever reach and angle. Rotate the brake lever down so that your pointer finger (while resting on the lever) is in a straight line with your forearm. (i.e. no bend in the wrist) Another thing that has helped me is to adjust the reach or throw of the brake lever as close to the bar as possible. It puts excess strain on your hand to reach out with one finger while maintaining a deathgrip with the other four. The closer you get to making a fist around the bar, the better for your hands.